InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CEBPE

Summary

InnateDB Protein

IDBP-3100.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CEBPE

Protein Name

CCAAT/enhancer binding protein (C/EBP), epsilon

Synonyms

C/EBP-epsilon; CRP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000206513

InnateDB Gene

IDBG-3098 (CEBPE)

Protein Structure

UniProt Annotation

Function

C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	63 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006909	phagocytosis
GO:0006952	defense response
GO:0010628	positive regulation of gene expression
GO:0030099	myeloid cell differentiation
GO:0030225	macrophage differentiation
GO:0042089	cytokine biosynthetic process
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071222	cellular response to lipopolysaccharide