InnateDB Protein
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IDBP-31004.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HOMER1
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Protein Name
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homer homolog 1 (Drosophila)
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Synonyms
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HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47; Ves-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000334382
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InnateDB Gene
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IDBG-31002 (HOMER1)
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Protein Structure
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Function |
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated |
Total |
18
[view]
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Protein-Protein |
18
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000697
WH1/EVH1
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PFAM |
PF00568
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PRINTS |
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PIRSF |
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SMART |
SM00461
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TIGRFAMs |
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Modification |
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SwissProt |
Q86YM7
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PhosphoSite |
PhosphoSite-Q86YM7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9456
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UniGene |
Hs.591761
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RefSeq |
NP_004263
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HUGO |
HGNC:17512
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OMIM |
604798
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CCDS |
CCDS43335
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HPRD |
09211
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IMGT |
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EMBL |
AF093262
AK312481
AY189939
AY189941
BC015502
BT009846
CH471084
Y17829
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GenPept |
AAC71026
AAH15502
AAO38999
AAO39001
AAP88848
BAG35385
CAA76877
EAW95836
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