InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HOMER1

Summary

InnateDB Gene

IDBG-31002.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOMER1

Gene Name

homer homolog 1 (Drosophila)

Synonyms

HOMER; HOMER1A; HOMER1B; HOMER1C; SYN47; Ves-1

Species

Homo sapiens

Ensembl Gene

ENSG00000152413

Encoded Proteins

IDBP-31004

homer homolog 1 (Drosophila)

IDBP-31006

homer homolog 1 (Drosophila)

IDBP-478884

homer homolog 1 (Drosophila)

IDBP-584459

homer homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:79372636-79514217

Strand

Reverse strand

Band

q14.1

Transcripts

ENST00000334082	ENSP00000334382
ENST00000282260	ENSP00000282260
ENST00000460741
ENST00000508576	ENSP00000426651
ENST00000535690	ENSP00000441587

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0031802	type 5 metabotropic glutamate receptor binding
GO:0032947	protein complex scaffold
GO:0035256	G-protein coupled glutamate receptor binding
GO:0035591	signaling adaptor activity
GO:0042802	identical protein binding
GO:0044325	ion channel binding
GO:0046982	protein heterodimerization activity
GO:0097110	scaffold protein binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway
GO:0007216	G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007623	circadian rhythm
GO:0009967	positive regulation of signal transduction
GO:0035094	response to nicotine
GO:0035418	protein localization to synapse
GO:0042220	response to cocaine
GO:0048148	behavioral response to cocaine
GO:0048741	skeletal muscle fiber development
GO:0048875	chemical homeostasis within a tissue
GO:0051592	response to calcium ion
GO:0051928	positive regulation of calcium ion transport
GO:0090279	regulation of calcium ion import
GO:2001256	regulation of store-operated calcium entry
GO:2001257	regulation of cation channel activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030018	Z disc
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043034	costamere
GO:0043198	dendritic shaft
GO:0045177	apical part of cell
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060076	excitatory synapse
GO:0097481	neuronal postsynaptic density

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000007617

View Gene Order

ENSBTAG00000025853

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.591761

RefSeq

NM_001277077 NM_001277078 NM_004272

HUGO

OMIM

CCDS

CCDS43335 CCDS64188 CCDS64189

HPRD

09211

IMGT

EMBL

GenPept

RNA Seq Atlas