InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKTIP

Summary

InnateDB Protein

IDBP-31051.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKTIP

Protein Name

AKT interacting protein

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000300245

InnateDB Gene

IDBG-31049 (AKTIP)

Protein Structure

UniProt Annotation

Function

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. {ECO:0000269PubMed:14749367, ECO:0000269PubMed:18799622}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:14749367}. Cell membrane {ECO:0000269PubMed:14749367}; Peripheral membrane protein {ECO:0000269PubMed:14749367}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006915	apoptotic process
GO:0007032	endosome organization
GO:0007040	lysosome organization
GO:0008152	metabolic process
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0032092	positive regulation of protein binding
GO:0045022	early endosome to late endosome transport