Version 5.4
Homo sapiens Gene: AKTIP
Summary
InnateDB Gene IDBG-31049.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKTIP
Gene Name AKT interacting protein
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000166971
Encoded Proteins
IDBP-31051
AKT interacting protein
IDBP-241147
AKT interacting protein
IDBP-750542
IDBP-747158
IDBP-747843
IDBP-754107
IDBP-752368
IDBP-749650
IDBP-747603
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:53491040-53504411
Strand Reverse strand
Band q12.2
Transcripts
ENST00000300245 ENSP00000300245
ENST00000394657 ENSP00000378152
ENST00000561799
ENST00000565431
ENST00000563108
ENST00000568022 ENSP00000454269
ENST00000570004 ENSP00000455874
ENST00000563928 ENSP00000456418
ENST00000568596 ENSP00000454771
ENST00000564497 ENSP00000456398
ENST00000565408 ENSP00000458118
ENST00000566045
ENST00000570041 ENSP00000456922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006915 apoptotic process
GO:0007032 endosome organization
GO:0007040 lysosome organization
GO:0008152 metabolic process
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0032092 positive regulation of protein binding
GO:0045022 early endosome to late endosome transport
Cellular Component
GO:0005886 plasma membrane
GO:0030897 HOPS complex
GO:0070695 FHF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031667
View Gene Order
ENSBTAG00000016250
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001012398 NM_022476 XM_005256094 XM_005256095 XM_005256096 XM_005256097 XM_005256098
HUGO
OMIM
CCDS CCDS10749
HPRD 07467
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca