InnateDB Protein
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IDBP-31116.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PILRA
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Protein Name
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paired immunoglobin-like type 2 receptor alpha
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000198536
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InnateDB Gene
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IDBG-31114 (PILRA)
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Protein Structure
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Function |
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. {ECO:0000269PubMed:10903717, ECO:0000269PubMed:18358807, ECO:0000269PubMed:21241660}.
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Subcellular Localization |
Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 2: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Secreted {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors. {ECO:0000269PubMed:10903717}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003599
Immunoglobulin subtype
IPR007110
Immunoglobulin-like domain
IPR013106
Immunoglobulin V-set domain
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PFAM |
PF07686
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PRINTS |
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PIRSF |
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SMART |
SM00409
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UKJ1
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PhosphoSite |
PhosphoSite-Q9UKJ1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
29992
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UniGene |
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RefSeq |
NP_038467
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HUGO |
HGNC:20396
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OMIM |
605341
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CCDS |
CCDS5691
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HPRD |
05631
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IMGT |
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EMBL |
AC005071
AF161080
AJ400841
AJ400842
AJ400843
BC017812
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GenPept |
AAD52964
AAH17812
CAC01613
CAC01614
CAC01615
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