Version 5.4
Homo sapiens Protein: PILRA
Summary
InnateDB Protein IDBP-31116.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PILRA
Protein Name paired immunoglobin-like type 2 receptor alpha
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000198536
InnateDB Gene IDBG-31114 (PILRA)
Protein Structure
UniProt Annotation
Function Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. {ECO:0000269PubMed:10903717, ECO:0000269PubMed:18358807, ECO:0000269PubMed:21241660}.
Subcellular Localization Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 2: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Predominantly detected in hemopoietic tissues and is expressed by monocytes, macrophages, and granulocytes, but not by lymphocytes. Also strongly expressed by dendritic cells (DC); preferentially by CD14+/CD1a- DC derived from CD34+ progenitors. Also expressed by CD11c+ blood and tonsil DC, but not by CD11c- DC precursors. {ECO:0000269PubMed:10903717}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0016032 viral process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UKJ1
PhosphoSite PhosphoSite-Q9UKJ1
TrEMBL
UniProt Splice Variant
Entrez Gene 29992
UniGene
RefSeq NP_038467
HUGO HGNC:20396
OMIM 605341
CCDS CCDS5691
HPRD 05631
IMGT
EMBL AC005071 AF161080 AJ400841 AJ400842 AJ400843 BC017812
GenPept AAD52964 AAH17812 CAC01613 CAC01614 CAC01615

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca