InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP44

Summary

InnateDB Protein

IDBP-31156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP44

Protein Name

Rho GTPase activating protein 44

Synonyms

NPC-A-10; RICH2;

Species

Homo sapiens

Ensembl Protein

ENSP00000368994

InnateDB Gene

IDBG-31150 (ARHGAP44)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP- bound states. May act as a GAP for CDC42 and RAC1. Endosomal recycling protein which, in association with SHANK3, is involved in synaptic plasticity. Promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation. {ECO:0000269PubMed:11431473}.

Subcellular Localization

Cell projection, dendritic spine {ECO:0000250}. Recycling endosome {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain. Expressed at weak level in other tissues. {ECO:0000269PubMed:11431473}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0006887	exocytosis
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030054	cell junction
GO:0031256	leading edge membrane
GO:0043197	dendritic spine
GO:0045202	synapse
GO:0055037	recycling endosome