InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADH7

Summary

InnateDB Protein

IDBP-31335.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADH7

Protein Name

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Synonyms

ADH4;

Species

Homo sapiens

Ensembl Protein

ENSP00000209665

InnateDB Gene

IDBG-31333 (ADH7)

Protein Structure

UniProt Annotation

Function

Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Preferentially expressed in stomach.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004022	alcohol dehydrogenase (NAD) activity
GO:0004024	alcohol dehydrogenase activity, zinc-dependent
GO:0004031	aldehyde oxidase activity
GO:0004745	retinol dehydrogenase activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0019841	retinol binding
GO:0035276	ethanol binding
GO:0048019	receptor antagonist activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0006069	ethanol oxidation
GO:0006805	xenobiotic metabolic process
GO:0009617	response to bacterium
GO:0010430	fatty acid omega-oxidation
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0055114	oxidation-reduction process
GO:1900116	extracellular negative regulation of signal transduction