InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CALR

Summary

InnateDB Protein

IDBP-31412.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CALR

Protein Name

calreticulin

Synonyms

cC1qR; CRT; HEL-S-99n; RO; SSA;

Species

Homo sapiens

Ensembl Protein

ENSP00000320866

InnateDB Gene

IDBG-31410 (CALR)

Protein Structure

UniProt Annotation

Function

Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen {ECO:0000250}. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	109 [view]
Protein-Protein	104 [view]
Protein-DNA	4 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001849	complement component C1q binding
GO:0001948	glycoprotein binding
GO:0003677	DNA binding
GO:0003729	mRNA binding
GO:0005178	integrin binding
GO:0005506	iron ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0030246	carbohydrate binding
GO:0031625	ubiquitin protein ligase binding
GO:0042277	peptide binding
GO:0042562	hormone binding
GO:0044183	protein binding involved in protein folding
GO:0044822	poly(A) RNA binding
GO:0050681	androgen receptor binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002502	peptide antigen assembly with MHC class I protein complex
GO:0006355	regulation of transcription, DNA-templated
GO:0006457	protein folding
GO:0006611	protein export from nucleus
GO:0006874	cellular calcium ion homeostasis
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007050	cell cycle arrest
GO:0007283	spermatogenesis
GO:0008284	positive regulation of cell proliferation
GO:0010033	response to organic substance
GO:0010628	positive regulation of gene expression
GO:0017148	negative regulation of translation
GO:0018279	protein N-linked glycosylation via asparagine
GO:0022417	protein maturation by protein folding
GO:0030866	cortical actin cytoskeleton organization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032355	response to estradiol
GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033574	response to testosterone
GO:0034504	protein localization to nucleus
GO:0040020	regulation of meiosis
GO:0042493	response to drug
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042921	glucocorticoid receptor signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045665	negative regulation of neuron differentiation
GO:0045740	positive regulation of DNA replication
GO:0045787	positive regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048387	negative regulation of retinoic acid receptor signaling pathway
GO:0050766	positive regulation of phagocytosis
GO:0050821	protein stabilization
GO:0051208	sequestering of calcium ion
GO:0055007	cardiac muscle cell differentiation
GO:0061077	chaperone-mediated protein folding
GO:0071285	cellular response to lithium ion
GO:0071310	cellular response to organic substance
GO:0090398	cellular senescence
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:2000510	positive regulation of dendritic cell chemotaxis

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005790	smooth endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005844	polysome
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016529	sarcoplasmic reticulum
GO:0031012	extracellular matrix
GO:0033018	sarcoplasmic reticulum lumen
GO:0042824	MHC class I peptide loading complex
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane
GO:0071682	endocytic vesicle lumen