InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AZIN1

Summary

InnateDB Protein

IDBP-31431.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AZIN1

Protein Name

antizyme inhibitor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000321507

InnateDB Gene

IDBG-31427 (AZIN1)

Protein Structure

UniProt Annotation

Function

Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. {ECO:0000269PubMed:17900240}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	7 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004857	enzyme inhibitor activity
GO:0042978	ornithine decarboxylase activator activity

Biological Process

GO:0006521	regulation of cellular amino acid metabolic process
GO:0006596	polyamine biosynthetic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0042177	negative regulation of protein catabolic process
GO:0043085	positive regulation of catalytic activity
GO:0043086	negative regulation of catalytic activity
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000183 Ornithine/DAP/Arg decarboxylase
IPR002433 Ornithine decarboxylase
IPR009006 Alanine racemase/group IV decarboxylase, C-terminal
IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal
IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal
IPR029066 PLP-binding barrel

PFAM

PF00278
PF02784

PRINTS

PR01179
PR01182

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O14977