InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN23

Summary

InnateDB Protein

IDBP-31482.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN23

Protein Name

protein tyrosine phosphatase, non-receptor type 23

Synonyms

HD-PTP; HDPTP; PTP-TD14;

Species

Homo sapiens

Ensembl Protein

ENSP00000265562

InnateDB Gene

IDBG-31480 (PTPN23)

Protein Structure

UniProt Annotation

Function

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis. {ECO:0000269PubMed:18434552, ECO:0000269PubMed:20393563, ECO:0000269PubMed:21757351}.

Subcellular Localization

Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0015031	protein transport
GO:0016311	dephosphorylation
GO:0030334	regulation of cell migration
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0060271	cilium morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0036064	ciliary basal body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR004328 BRO1 domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF03097

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM01041

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt