InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CES1

Summary

InnateDB Protein

IDBP-31496.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CES1

Protein Name

carboxylesterase 1

Synonyms

ACAT; CE-1; CEH; CES2; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH;

Species

Homo sapiens

Ensembl Protein

ENSP00000355193

InnateDB Gene

IDBG-31492 (CES1)

Protein Structure

UniProt Annotation

Function

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. {ECO:0000269PubMed:7980644, ECO:0000269PubMed:9169443}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000269PubMed:10562416}.

Disease Associations

Tissue Specificity

Expressed predominantly in liver with lower levels in heart and lung. {ECO:0000269PubMed:10562416}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016787	hydrolase activity
GO:0047374	methylumbelliferyl-acetate deacetylase activity
GO:0052689	carboxylic ester hydrolase activity