Version 5.4
Homo sapiens Gene: CES1
Summary
InnateDB Gene IDBG-31492.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CES1
Gene Name carboxylesterase 1
Synonyms ACAT; CE-1; CEH; CES2; hCE-1; HMSE; HMSE1; PCE-1; REH; SES1; TGH
Species Homo sapiens
Ensembl Gene ENSG00000198848
Encoded Proteins
IDBP-31496
carboxylesterase 1
IDBP-31544
carboxylesterase 1
IDBP-377212
carboxylesterase 1
IDBP-747701
IDBP-751599
IDBP-748217
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:55802851-55833337
Strand Reverse strand
Band q12.2
Transcripts
ENST00000361503 ENSP00000355193
ENST00000360526 ENSP00000353720
ENST00000422046 ENSP00000390492
ENST00000565403
ENST00000563005
ENST00000563241 ENSP00000455959
ENST00000569260 ENSP00000456865
ENST00000566555
ENST00000565568 ENSP00000455902
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0047374 methylumbelliferyl-acetate deacetylase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0009636 response to toxic substance
GO:0030855 epithelial cell differentiation
Cellular Component
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000056973
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa00983
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.558865
RefSeq NM_001025194 NM_001025195 NM_001266 XM_005255774 XM_005276867 XM_006726229
HUGO
OMIM
CCDS CCDS32450 CCDS45488 CCDS45489
HPRD 00268
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca