Version 5.4
Homo sapiens Protein: SYNM
Summary
InnateDB Protein IDBP-31551.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYNM
Protein Name synemin, intermediate filament protein
Synonyms DMN; SYN;
Species Homo sapiens
Ensembl Protein ENSP00000336775
InnateDB Gene IDBG-31547 (SYNM)
Protein Structure
UniProt Annotation
Function Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. {ECO:0000269PubMed:11353857, ECO:0000269PubMed:16777071, ECO:0000269PubMed:18028034}.
Subcellular Localization Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z- lines, and another in which it interacts with both DTNA and DES at the costamere.
Disease Associations
Tissue Specificity Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms. {ECO:0000269PubMed:11353857, ECO:0000269PubMed:11737198}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0017166 vinculin binding
GO:0019215 intermediate filament binding
Biological Process
GO:0045104 intermediate filament cytoskeleton organization
Cellular Component
GO:0005882 intermediate filament
GO:0005912 adherens junction
GO:0016020 membrane
GO:0043034 costamere
GO:0060053 neurofilament cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001664 Intermediate filament protein
PFAM PF00038
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O15061
PhosphoSite PhosphoSite-O15061
TrEMBL
UniProt Splice Variant
Entrez Gene 23336
UniGene Hs.207106
RefSeq NP_663780
HUGO HGNC:24466
OMIM 606087
CCDS CCDS73787
HPRD 07305
IMGT
EMBL AB002351 AF359284 AJ310521 AJ310522 AJ697971 BC110066 BC151243
GenPept AAI10067 AAI51244 AAK57487 BAA20810 CAC83858 CAC83859 CAG27071

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca