Version 5.4
Homo sapiens Gene: SYNM
Summary
InnateDB Gene IDBG-31547.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYNM
Gene Name synemin, intermediate filament protein
Synonyms DMN; SYN
Species Homo sapiens
Ensembl Gene ENSG00000182253
Encoded Proteins
IDBP-31549
synemin, intermediate filament protein
IDBP-31551
synemin, intermediate filament protein
IDBP-588958
synemin, intermediate filament protein
IDBP-809882
synemin, intermediate filament protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an intermediate filament (IF) family member. IF proteins are cytoskeletal proteins that confer resistance to mechanical stress and are encoded by a dispersed multigene family. This protein has been found to form a linkage between desmin, which is a subunit of the IF network, and the extracellular matrix, and provides an important structural support in muscle. Two alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:99098217-99135593
Strand Forward strand
Band q26.3
Transcripts
ENST00000328642 ENSP00000330469
ENST00000336292 ENSP00000336775
ENST00000560674 ENSP00000453040
ENST00000594047 ENSP00000472953
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
GO:0005515 protein binding
GO:0008307 structural constituent of muscle
GO:0017166 vinculin binding
GO:0019215 intermediate filament binding
Biological Process
GO:0045104 intermediate filament cytoskeleton organization
Cellular Component
GO:0005882 intermediate filament
GO:0005912 adherens junction
GO:0016020 membrane
GO:0043034 costamere
GO:0060053 neurofilament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030554
View Gene Order
ENSBTAG00000011752
Not yet available
Cross-References
SwissProt
TrEMBL H0YL34
UniProt Splice Variant
Entrez Gene 23336
UniGene Hs.207106
RefSeq NM_015286 NM_145728
HUGO HGNC:24466
OMIM 606087
CCDS CCDS73786 CCDS73787
HPRD 07305
IMGT
EMBL AC036108
GenPept
RNA Seq Atlas 23336

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca