InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUDT15

Summary

InnateDB Protein

IDBP-31580.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT15

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000258662

InnateDB Gene

IDBG-31578 (NUDT15)

Protein Structure

UniProt Annotation

Function

Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8- oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression through the interaction with PCNA. {ECO:0000250, ECO:0000269PubMed:19419956, ECO:0000269PubMed:22556419}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008413	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0016787	hydrolase activity
GO:0035539	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006203	dGTP catabolic process
GO:0034656	nucleobase-containing small molecule catabolic process
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process