Version 5.4
Homo sapiens Protein: PCOLCE
Summary
InnateDB Protein IDBP-31592.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCOLCE
Protein Name procollagen C-endopeptidase enhancer
Synonyms PCPE; PCPE-1; PCPE1;
Species Homo sapiens
Ensembl Protein ENSP00000223061
InnateDB Gene IDBG-31590 (PCOLCE)
Protein Structure
UniProt Annotation
Function Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0008201 heparin binding
GO:0016504 peptidase activator activity
Biological Process
GO:0006508 proteolysis
GO:0007275 multicellular organismal development
GO:0010952 positive regulation of peptidase activity
Cellular Component
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000859 CUB domain
IPR001134 Netrin domain
IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
IPR018933 Netrin module, non-TIMP type
PFAM PF00431
PF01759
PRINTS
PIRSF
SMART SM00042
SM00643
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15113
PhosphoSite PhosphoSite-Q15113
TrEMBL
UniProt Splice Variant
Entrez Gene 5118
UniGene Hs.202097
RefSeq NP_002584
HUGO HGNC:8738
OMIM 600270
CCDS CCDS5700
HPRD 02603
IMGT
EMBL AB008549 AF053356 AF083655 AK313748 BC000574 BC033205 CH471091 L33799
GenPept AAA61949 AAC78800 AAD16041 AAH00574 AAH33205 BAA23281 BAG36488 EAW76515

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca