InnateDB Protein
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IDBP-31598.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MCRS1
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Protein Name
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microspherule protein 1
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Synonyms
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ICP22BP; INO80Q; MCRS2; MSP58; P78;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000345358
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InnateDB Gene
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IDBG-31596 (MCRS1)
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Protein Structure
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Function |
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. {ECO:0000269PubMed:11948183, ECO:0000269PubMed:15044100, ECO:0000269PubMed:20018852}.
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Subcellular Localization |
Nucleus. Nucleus, nucleolus. Note=In microspherules in the nucleolus.
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Disease Associations |
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Tissue Specificity |
Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
64
[view]
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Protein-Protein |
64
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0043995
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histone acetyltransferase activity (H4-K5 specific)
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GO:0043996
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histone acetyltransferase activity (H4-K8 specific)
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GO:0046972
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histone acetyltransferase activity (H4-K16 specific)
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000253
Forkhead-associated (FHA) domain
IPR008984
SMAD/FHA domain
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PFAM |
PF00498
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PRINTS |
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PIRSF |
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SMART |
SM00240
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TIGRFAMs |
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Modification |
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SwissProt |
Q96EZ8
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PhosphoSite |
PhosphoSite-Q96EZ8
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TrEMBL |
F8W126
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UniProt Splice Variant |
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Entrez Gene |
10445
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UniGene |
Hs.25313
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RefSeq |
NP_006328
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HUGO |
HGNC:6960
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OMIM |
609504
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CCDS |
CCDS8787
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HPRD |
11298
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IMGT |
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EMBL |
AC020612
AF015308
AF068007
AY336730
BC011794
BX538079
CH471111
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GenPept |
AAC52086
AAC68599
AAH11794
AAQ84517
CAD98003
EAW58078
EAW58079
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