InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MCRS1

Summary

InnateDB Protein

IDBP-31600.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCRS1

Protein Name

microspherule protein 1

Synonyms

ICP22BP; INO80Q; MCRS2; MSP58; P78;

Species

Homo sapiens

Ensembl Protein

ENSP00000349640

InnateDB Gene

IDBG-31596 (MCRS1)

Protein Structure

UniProt Annotation

Function

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. {ECO:0000269PubMed:11948183, ECO:0000269PubMed:15044100, ECO:0000269PubMed:20018852}.

Subcellular Localization

Nucleus. Nucleus, nucleolus. Note=In microspherules in the nucleolus.

Disease Associations

Tissue Specificity

Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043995	histone acetyltransferase activity (H4-K5 specific)
GO:0043996	histone acetyltransferase activity (H4-K8 specific)
GO:0046972	histone acetyltransferase activity (H4-K16 specific)

Biological Process

GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006464	cellular protein modification process
GO:0043981	histone H4-K5 acetylation
GO:0043982	histone H4-K8 acetylation
GO:0043984	histone H4-K16 acetylation