Version 5.4
Homo sapiens Protein: MED4
Summary
InnateDB Protein IDBP-31619.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED4
Protein Name mediator complex subunit 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000258648
InnateDB Gene IDBG-31615 (MED4)
Protein Structure
UniProt Annotation
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0003712 transcription cofactor activity
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0042809 vitamin D receptor binding
GO:0046966 thyroid hormone receptor binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0010467 gene expression
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016592 mediator complex
Protein Structure and Domains
PDB ID
InterPro IPR019258 Mediator complex, subunit Med4
PFAM PF10018
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NPJ6
PhosphoSite PhosphoSite-Q9NPJ6
TrEMBL A0A024RDY7
UniProt Splice Variant
Entrez Gene 29079
UniGene Hs.741275
RefSeq NP_054885
HUGO HGNC:17903
OMIM 605718
CCDS CCDS9408
HPRD 16145
IMGT
EMBL AF161475 AF230381 AF300618 AK001934 AK222713 AK223017 AK301835 AL158196 BC005189 CH471075 CR457276 CR541830
GenPept AAF29090 AAF37289 AAG22542 AAH05189 BAA91987 BAD96433 BAD96737 BAG63279 CAG33557 CAG46629 CAI17018 CAI17020 EAX08784 EAX08785

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca