InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MED4

Summary

InnateDB Gene

IDBG-31615.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED4

Gene Name

mediator complex subunit 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000136146

Encoded Proteins

IDBP-31619

mediator complex subunit 4

IDBP-31621

mediator complex subunit 4

IDBP-367909

mediator complex subunit 4

IDBP-810406

mediator complex subunit 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:48053323-48095131

Strand

Reverse strand

Band

q14.2

Transcripts

ENST00000258648	ENSP00000258648
ENST00000378586	ENSP00000367849
ENST00000417167	ENSP00000413595
ENST00000495013	ENSP00000483651

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	79 [view]
Protein-Protein	79 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003712	transcription cofactor activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0042809	vitamin D receptor binding
GO:0046966	thyroid hormone receptor binding

Biological Process

GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030521	androgen receptor signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated