InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM16

Summary

InnateDB Protein

IDBP-31695.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM16

Protein Name

tripartite motif containing 16

Synonyms

EBBP;

Species

Homo sapiens

Ensembl Protein

ENSP00000338989

InnateDB Gene

IDBG-281555 (TRIM16)

Protein Structure

UniProt Annotation

Function

May play a role in the regulation of keratinocyte differentiation.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019966	interleukin-1 binding
GO:0032089	NACHT domain binding

Biological Process

GO:0032526	response to retinoic acid
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046683	response to organophosphorus
GO:0048386	positive regulation of retinoic acid receptor signaling pathway
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0060416	response to growth hormone

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0016605	PML body

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR006574 SPRY-associated
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM

PF00643
PF00622
PF13765

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00449
SM00589

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt