InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GNAO1

Summary

InnateDB Protein

IDBP-31704.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNAO1

Protein Name

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

Synonyms

EIEE17; G-ALPHA-o; GNAO;

Species

Homo sapiens

Ensembl Protein

ENSP00000262494

InnateDB Gene

IDBG-31702 (GNAO1)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.

Subcellular Localization

Cell membrane {ECO:0000250}.

Disease Associations

Epileptic encephalopathy, early infantile, 17 (EIEE17) [MIM:615473]: A severe neurologic disorder characterized by onset of intractable seizures in the first weeks or months of life and usually associated with EEG abnormalities. Affected infants have very poor psychomotor development and may have brain abnormalities, such as cerebral atrophy or thin corpus callosum. Some patients may show involuntary movements. {ECO:0000269PubMed:23993195}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0031821	G-protein coupled serotonin receptor binding
GO:0031852	mu-type opioid receptor binding
GO:0032403	protein complex binding
GO:0032794	GTPase activating protein binding
GO:0046872	metal ion binding
GO:0051430	corticotropin-releasing hormone receptor 1 binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006936	muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007212	dopamine receptor signaling pathway
GO:0007568	aging
GO:0007626	locomotory behavior
GO:0008016	regulation of heart contraction
GO:0009987	cellular process
GO:0010243	response to organonitrogen compound
GO:0014070	response to organic cyclic compound
GO:0030900	forebrain development
GO:0031175	neuron projection development
GO:0034097	response to cytokine
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043278	response to morphine
GO:0043547	positive regulation of GTPase activity
GO:0051926	negative regulation of calcium ion transport

Cellular Component

GO:0005622	intracellular
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043005	neuron projection
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001408 G-protein alpha subunit, group I
IPR002975 Fungal G-protein, alpha subunit
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR011025 G protein alpha subunit, helical insertion
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00025

PRINTS

PR00318
PR00441
PR01241
PR00328

PIRSF

SMART

SM00275

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt