Homo sapiens Gene: GNAO1

Summary
InnateDB Gene IDBG-31702.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol GNAO1
Gene Name guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Synonyms G-ALPHA-o; GNAO
Species Homo sapiens
Ensembl Gene ENSG00000087258
Encoded Proteins
IDBP-31704 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
IDBP-31706 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
IDBP-754048
IDBP-749930
IDBP-750630
IDBP-748701
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16: 56225302-56391356
Strand Forward strand
Band q12.2
Transcripts
ENST00000262494  ENSP00000262494
ENST00000262493  ENSP00000262493
ENST00000563440  ENSP00000455774
ENST00000563661 
ENST00000562316  ENSP00000457238
ENST00000564727  ENSP00000454971
ENST00000565363  ENSP00000454728
ENST00000564798 
ENST00000569295 
ENST00000568375 
ENST00000570235 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein‑Protein  20
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031821 G-protein coupled serotonin receptor binding
GO:0031852 mu-type opioid receptor binding
GO:0032403 protein complex binding
GO:0046872 metal ion binding
GO:0051430 corticotropin-releasing hormone receptor 1 binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007568 aging
GO:0007626 locomotory behavior
GO:0008016 regulation of heart contraction
GO:0009987 cellular process
GO:0010243 response to organic nitrogen
GO:0014070 response to organic cyclic compound
GO:0030900 forebrain development
GO:0031175 neuron projection development
GO:0034097 response to cytokine stimulus
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043278 response to morphine
GO:0043547 positive regulation of GTPase activity
GO:0051926 negative regulation of calcium ion transport
Cellular Component
GO:0005622 intracellular
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031234 extrinsic to internal side of plasma membrane
GO:0043005 neuron projection
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000031748 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000003794 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
NetPath_23 TSH pathway
REACTOME
REACT_15457 G-protein activation
REACT_15426 PLC beta mediated events
KEGG
hsa05142  Chagas disease (American trypanosomiasis)
hsa04730  Long-term depression
hsa04916  Melanogenesis
hsa05145  Toxoplasmosis
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P09471 
TrEMBL H3BN82 H3BNR5 H3BQG8 H3BTM2 Q6AWC5 Q8N6I9
UniProt Splice Variant
Entrez Gene 2775 
UniGene Hs.644524 Hs.654647 Hs.719038
RefSeq NM_020988  NM_138736 
HUGO 4389 
OMIM 139311
CCDS CCDS10756  CCDS10757 
HPRD 00757
IMGT
EMBL AC009102 AC079411 AF493894 AF493895 BC030027 BX647214 M19182 M19184 M60156 M60157 M60158 M60159 M60160 M60161 M60162 M60163 M60164 Y18213
GenPept AAA52584  AAA52585  AAA52586  AAH30027  AAM12608  AAM12609  CAB46639  CAH10548 
ImmGen GNAO1 (murine) 
RNA Seq Atlas 2775