Homo sapiens Gene: GNAO1
Summary
InnateDB Gene IDBG-31702.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol GNAO1
Gene Name guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Synonyms G-ALPHA-o; GNAO;
Species Homo sapiens
Ensembl Gene ENSG00000087258
Encoded Proteins
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Protein Structure
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 16:56225302-56391356
Strand Forward strand
Band q12.2
Transcripts
ENST00000262494 ENSP00000262494
ENST00000262493 ENSP00000262493
ENST00000563440 ENSP00000455774
ENST00000563661
ENST00000562316 ENSP00000457238
ENST00000564727 ENSP00000454971
ENST00000565363 ENSP00000454728
ENST00000564798
ENST00000569295
ENST00000568375
ENST00000570235
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031821 G-protein coupled serotonin receptor binding
GO:0031852 mu-type opioid receptor binding
GO:0032403 protein complex binding
GO:0046872 metal ion binding
GO:0051430 corticotropin-releasing hormone receptor 1 binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007568 aging
GO:0007626 locomotory behavior
GO:0008016 regulation of heart contraction
GO:0009987 cellular process
GO:0010243 response to organic nitrogen
GO:0014070 response to organic cyclic compound
GO:0030900 forebrain development
GO:0031175 neuron projection development
GO:0034097 response to cytokine stimulus
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0043278 response to morphine
GO:0043547 positive regulation of GTPase activity
GO:0051926 negative regulation of calcium ion transport
Cellular Component
GO:0005622 intracellular
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031234 extrinsic to internal side of plasma membrane
GO:0043005 neuron projection
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSH pathway
REACTOME
PLC beta mediated events pathway
G-protein activation pathway
KEGG
Chagas disease (American trypanosomiasis) pathway
Toxoplasmosis pathway
Long-term depression pathway
Melanogenesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P09471
TrEMBL H3BN82 H3BNR5 H3BQG8 H3BTM2 Q6AWC5 Q8N6I9
UniProt Splice Variant
Entrez Gene 2775
UniGene Hs.644524 Hs.654647 Hs.719038
RefSeq NM_020988 NM_138736
HUGO 4389
OMIM 139311
CCDS CCDS10756 CCDS10757
HPRD 00757
IMGT
EMBL AC009102 AC079411 AF493894 AF493895 BC030027 BX647214 M19182 M19184 M60156 M60157 M60158 M60159 M60160 M60161 M60162 M60163 M60164 Y18213
GenPept AAA52584 AAA52585 AAA52586 AAH30027 AAM12608 AAM12609 CAB46639 CAH10548
ImmGen GNAO1 (murine)
RNA Seq Atlas 2775