InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: H2AFZ

Summary

InnateDB Protein

IDBP-31709.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2AFZ

Protein Name

H2A histone family, member Z

Synonyms

H2A.z; H2A.Z-1; H2A/z; H2AZ;

Species

Homo sapiens

Ensembl Protein

ENSP00000296417

InnateDB Gene

IDBG-31707 (H2AFZ)

Protein Structure

UniProt Annotation

Function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. {ECO:0000269PubMed:15878876}.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	62 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0031492	nucleosomal DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006334	nucleosome assembly
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071392	cellular response to estradiol stimulus