InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRMT1

Summary

InnateDB Protein

IDBP-31769.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRMT1

Protein Name

TRM1 tRNA methyltransferase 1 homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000221504

InnateDB Gene

IDBG-31765 (TRMT1)

Protein Structure

UniProt Annotation

Function

Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0004809	tRNA (guanine-N2-)-methyltransferase activity
GO:0016740	transferase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0008033	tRNA processing
GO:0030488	tRNA methylation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000571 Zinc finger, CCCH-type
IPR002905 tRNA methyltransferase, Trm1
IPR003402 tRNA transferase Trm5/Tyw2
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00642
PF02005
PF02475

PRINTS

PIRSF

SMART

SM00356

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NXH9