InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RIMS2

Summary

InnateDB Protein

IDBP-31876.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RIMS2

Protein Name

regulating synaptic membrane exocytosis 2

Synonyms

OBOE; RAB3IP3; RIM2;

Species

Homo sapiens

Ensembl Protein

ENSP00000262231

InnateDB Gene

IDBG-31870 (RIMS2)

Protein Structure

UniProt Annotation

Function

Rab effector involved in exocytosis. May act as scaffold protein.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017137	Rab GTPase binding
GO:0019904	protein domain specific binding
GO:0044325	ion channel binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006886	intracellular protein transport
GO:0017156	calcium ion-dependent exocytosis
GO:0017157	regulation of exocytosis
GO:0019933	cAMP-mediated signaling
GO:0030073	insulin secretion
GO:0042391	regulation of membrane potential
GO:0048791	calcium ion-dependent exocytosis of neurotransmitter