Version 5.4
Homo sapiens Protein: ITM2B
Summary
InnateDB Protein IDBP-31937.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITM2B
Protein Name integral membrane protein 2B
Synonyms ABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; imBRI2;
Species Homo sapiens
Ensembl Protein ENSP00000367811
InnateDB Gene IDBG-31933 (ITM2B)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005515 protein binding
Biological Process
GO:0007399 nervous system development
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0031301 integral component of organelle membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR007084 BRICHOS domain
PFAM PF04089
PRINTS
PIRSF
SMART SM01039
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y287
PhosphoSite PhosphoSite-Q9Y287
TrEMBL Q5W0A2
UniProt Splice Variant
Entrez Gene 9445
UniGene Hs.728465
RefSeq
HUGO HGNC:6174
OMIM 603904
CCDS
HPRD 04878
IMGT
EMBL AF092128 AF136973 AF152462 AF246221 AL139322 AY341247 BC000554 BC016148 BT006863 CH471075
GenPept AAD40370 AAD45280 AAF66130 AAG49434 AAH00554 AAH16148 AAP35509 AAP88930 EAX08789 EAX08790

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca