InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FAIM2

Summary

InnateDB Protein

IDBP-32036.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FAIM2

Protein Name

Fas apoptotic inhibitory molecule 2

Synonyms

LFG; LFG2; NGP35; NMP35; TMBIM2;

Species

Homo sapiens

Ensembl Protein

ENSP00000321951

InnateDB Gene

IDBG-32034 (FAIM2)

Protein Structure

UniProt Annotation

Function

Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. {ECO:0000269PubMed:10535980, ECO:0000269PubMed:17635665}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane raft {ECO:0000269PubMed:17635665}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus. {ECO:0000269PubMed:10535980, ECO:0000269PubMed:20336406}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0002931	response to ischemia
GO:0006915	apoptotic process
GO:0021549	cerebellum development
GO:0021680	cerebellar Purkinje cell layer development
GO:0021681	cerebellar granular layer development
GO:0021702	cerebellar Purkinje cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:2001234	negative regulation of apoptotic signaling pathway