InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DPYS

Summary

InnateDB Protein

IDBP-32050.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPYS

Protein Name

dihydropyrimidinase

Synonyms

DHP; DHPase;

Species

Homo sapiens

Ensembl Protein

ENSP00000276651

InnateDB Gene

IDBG-32048 (DPYS)

Protein Structure

UniProt Annotation

Function

Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.

Subcellular Localization

Disease Associations

Dihydropyrimidinase deficiency (DHPD) [MIM:222748]: A disorder characterized by dihydropyrimidinuria and associated with a variable clinical phenotype characterized by epileptic or convulsive attacks, dysmorphic features and severe developmental delay, and congenital microvillous atrophy. {ECO:0000269PubMed:9718352}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002058	uracil binding
GO:0002059	thymine binding
GO:0004157	dihydropyrimidinase activity
GO:0008270	zinc ion binding
GO:0016597	amino acid binding
GO:0016787	hydrolase activity
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0051219	phosphoprotein binding

Biological Process

GO:0006206	pyrimidine nucleobase metabolic process
GO:0006208	pyrimidine nucleobase catabolic process
GO:0006210	thymine catabolic process
GO:0006212	uracil catabolic process
GO:0019482	beta-alanine metabolic process
GO:0019860	uracil metabolic process
GO:0044281	small molecule metabolic process
GO:0046135	pyrimidine nucleoside catabolic process
GO:0051260	protein homooligomerization
GO:0051289	protein homotetramerization
GO:0055086	nucleobase-containing small molecule metabolic process