Version 5.4
Homo sapiens Protein: AQP6
Summary
InnateDB Protein IDBP-32174.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AQP6
Protein Name aquaporin 6, kidney specific
Synonyms AQP2L; KID;
Species Homo sapiens
Ensembl Protein ENSP00000320247
InnateDB Gene IDBG-32170 (AQP6)
Protein Structure
UniProt Annotation
Function Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005253 anion channel activity
GO:0015250 water channel activity
Biological Process
GO:0006810 transport
GO:0006833 water transport
GO:0007588 excretion
GO:0042476 odontogenesis
GO:0055085 transmembrane transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030658 transport vesicle membrane
Protein Structure and Domains
PDB ID
InterPro IPR000425 Major intrinsic protein
IPR023254 Aquaporin 6
IPR023271 Aquaporin-like
PFAM PF00230
PRINTS PR00783
PR02018
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13520
PhosphoSite PhosphoSite-Q13520
TrEMBL F8VW87
UniProt Splice Variant
Entrez Gene 363
UniGene
RefSeq
HUGO HGNC:639
OMIM 601383
CCDS CCDS31798
HPRD 03226
IMGT
EMBL AC025154 U48408
GenPept AAB41566

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca