InnateDB Protein
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IDBP-32206.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDC25A
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Protein Name
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cell division cycle 25 homolog A (S. pombe)
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Synonyms
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CDC25A2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000303706
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InnateDB Gene
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IDBG-32204 (CDC25A)
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Protein Structure
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Function |
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
87
[view]
|
Protein-Protein |
74
[view]
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Protein-DNA |
13
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000751
M-phase inducer phosphatase
IPR001763
Rhodanese-like domain
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PFAM |
PF06617
PF00581
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PRINTS |
PR00716
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PIRSF |
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SMART |
SM00450
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TIGRFAMs |
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Modification |
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SwissProt |
P30304
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PhosphoSite |
PhosphoSite-P30304
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TrEMBL |
K7N7S0
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UniProt Splice Variant |
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Entrez Gene |
993
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UniGene |
Hs.437705
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RefSeq |
NP_001780
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HUGO |
HGNC:1725
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OMIM |
116947
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CCDS |
CCDS2760
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HPRD |
00305
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IMGT |
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EMBL |
AC104190
AC124916
AF277722
AF527417
AY137580
BC007401
BC018642
CH471055
FJ866789
M81933
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GenPept |
AAA58415
AAG41884
AAH07401
AAH18642
AAM77917
AAN11305
ACZ05628
EAW64849
EAW64851
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