InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDC25A

Summary

InnateDB Protein

IDBP-32208.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDC25A

Protein Name

cell division cycle 25 homolog A (S. pombe)

Synonyms

CDC25A2;

Species

Homo sapiens

Ensembl Protein

ENSP00000343166

InnateDB Gene

IDBG-32204 (CDC25A)

Protein Structure

UniProt Annotation

Function

Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 87 experimentally validated interaction(s) in this database.

Experimentally validated
Total	87 [view]
Protein-Protein	74 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000087	mitotic M phase
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006470	protein dephosphorylation
GO:0007067	mitotic nuclear division
GO:0008283	cell proliferation
GO:0009314	response to radiation
GO:0034644	cellular response to UV
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0051726	regulation of cell cycle