Version 5.4
Homo sapiens Protein: XRCC4
Summary
InnateDB Protein IDBP-32223.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XRCC4
Protein Name X-ray repair complementing defective repair in Chinese hamster cells 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000342011
InnateDB Gene IDBG-32219 (XRCC4)
Protein Structure
UniProt Annotation
Function Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. {ECO:0000269PubMed:10757784, ECO:0000269PubMed:10854421, ECO:0000269PubMed:16412978, ECO:0000269PubMed:8548796}.
Subcellular Localization Nucleus {ECO:0000269PubMed:16478998, ECO:0000269PubMed:9259561}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:8548796}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
Experimentally validated
Total 46 [view]
Protein-Protein 43 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
Biological Process
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0010165 response to X-ray
GO:0016032 viral process
GO:0051103 DNA ligation involved in DNA repair
GO:0051351 positive regulation of ligase activity
GO:0075713 establishment of integrated proviral latency
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex
GO:0030054 cell junction
GO:0032807 DNA ligase IV complex
GO:0070419 nonhomologous end joining complex
Protein Structure and Domains
PDB ID
InterPro IPR009089 DNA double-strand break repair and VJ recombination XRCC4, N-terminal
IPR010585 DNA repair protein XRCC4
PFAM PF06632
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13426
PhosphoSite PhosphoSite-Q13426
TrEMBL A0A024RAQ8
UniProt Splice Variant
Entrez Gene 7518
UniGene Hs.567359
RefSeq NP_071801
HUGO HGNC:12831
OMIM 194363
CCDS CCDS4059
HPRD 15951
IMGT
EMBL AB017445 AF055279 AF055280 AF055281 AF055282 AF055283 AF055284 AF055285 AK290739 AY940097 BC005259 BC016314 BT007216 CH471084 U40622
GenPept AAC50339 AAD47297 AAD47298 AAH05259 AAH16314 AAP35880 AAX14046 BAB20668 BAF83428 EAW95898 EAW95900

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca