InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: XRCC4

Summary

InnateDB Gene

IDBG-32219.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRCC4

Gene Name

X-ray repair complementing defective repair in Chinese hamster cells 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000152422

Encoded Proteins

IDBP-32221

X-ray repair complementing defective repair in Chinese hamster cells 4

IDBP-32223

X-ray repair complementing defective repair in Chinese hamster cells 4

IDBP-238358

X-ray repair complementing defective repair in Chinese hamster cells 4

IDBP-479337

X-ray repair complementing defective repair in Chinese hamster cells 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:83077498-83353787

Strand

Forward strand

Band

q14.2

Transcripts

ENST00000282268	ENSP00000282268
ENST00000338635	ENSP00000342011
ENST00000396027	ENSP00000379344
ENST00000511817	ENSP00000421491
ENST00000509268
ENST00000542685

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.

Experimentally validated
Total	46 [view]
Protein-Protein	43 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0001701	in utero embryonic development
GO:0002328	pro-B cell differentiation
GO:0006266	DNA ligation
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0007417	central nervous system development
GO:0010165	response to X-ray
GO:0010212	response to ionizing radiation
GO:0010332	response to gamma radiation
GO:0016032	viral process
GO:0033077	T cell differentiation in thymus
GO:0033151	V(D)J recombination
GO:0033152	immunoglobulin V(D)J recombination
GO:0043524	negative regulation of neuron apoptotic process
GO:0045190	isotype switching
GO:0048146	positive regulation of fibroblast proliferation
GO:0050769	positive regulation of neurogenesis
GO:0051103	DNA ligation involved in DNA repair
GO:0051351	positive regulation of ligase activity
GO:0071285	cellular response to lithium ion
GO:0075713	establishment of integrated proviral latency

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex
GO:0030054	cell junction
GO:0032807	DNA ligase IV complex
GO:0070419	nonhomologous end joining complex