InnateDB Protein
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IDBP-32226.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DKK3
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Protein Name
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dickkopf homolog 3 (Xenopus laevis)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000314910
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InnateDB Gene
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IDBG-32224 (DKK3)
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Protein Structure
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Function |
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted.
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Disease Associations |
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Tissue Specificity |
Highest expression in heart, brain, and spinal cord. {ECO:0000269PubMed:10570958, ECO:0000269Ref.4}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0007275
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multicellular organismal development
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GO:0009653
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anatomical structure morphogenesis
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GO:0016055
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Wnt signaling pathway
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GO:0030178
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negative regulation of Wnt signaling pathway
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GO:0030325
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adrenal gland development
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GO:0032348
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negative regulation of aldosterone biosynthetic process
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0090090
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negative regulation of canonical Wnt signaling pathway
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GO:2000065
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negative regulation of cortisol biosynthetic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR006796
Dickkopf, N-terminal cysteine-rich
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PFAM |
PF04706
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBP4
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PhosphoSite |
PhosphoSite-Q9UBP4
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TrEMBL |
E9PKW6
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UniProt Splice Variant |
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Entrez Gene |
27122
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UniGene |
Hs.292156
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RefSeq |
NP_037385
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HUGO |
HGNC:2893
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OMIM |
605416
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CCDS |
CCDS7808
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HPRD |
05659
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IMGT |
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EMBL |
AB033421
AB034203
AB035182
AB057591
AB057804
AC124276
AF177396
AK289897
AY358378
BC007660
CH471064
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GenPept |
AAF02676
AAH07660
AAQ88744
BAA85488
BAA87044
BAA90548
BAB84360
BAB84361
BAF82586
EAW68534
EAW68535
EAW68537
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