InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANGPT1

Summary

InnateDB Protein

IDBP-32294.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANGPT1

Protein Name

angiopoietin 1

Synonyms

AGP1; AGPT; ANG1;

Species

Homo sapiens

Ensembl Protein

ENSP00000297450

InnateDB Gene

IDBG-32292 (ANGPT1)

Protein Structure

UniProt Annotation

Function

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. {ECO:0000269PubMed:15284220, ECO:0000269PubMed:18425119, ECO:0000269PubMed:18425120, ECO:0000269PubMed:9204896}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0001525	angiogenesis
GO:0002040	sprouting angiogenesis
GO:0002092	positive regulation of receptor internalization
GO:0007162	negative regulation of cell adhesion
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007596	blood coagulation
GO:0010595	positive regulation of endothelial cell migration
GO:0014842	regulation of satellite cell proliferation
GO:0030154	cell differentiation
GO:0030210	heparin biosynthetic process
GO:0031398	positive regulation of protein ubiquitination
GO:0034394	protein localization to cell surface
GO:0043066	negative regulation of apoptotic process
GO:0043116	negative regulation of vascular permeability
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0045087	innate immune response (InnateDB)
GO:0048014	Tie signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050900	leukocyte migration
GO:0050918	positive chemotaxis
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0072012	glomerulus vasculature development
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome