Version 5.4
Homo sapiens Protein: MRI1
Summary
InnateDB Protein IDBP-32309.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRI1
Protein Name methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000040663
InnateDB Gene IDBG-32307 (MRI1)
Protein Structure
UniProt Annotation
Function Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. {ECO:0000255HAMAP-Rule:MF_03119, ECO:0000269PubMed:19620624}.
Subcellular Localization Nucleus {ECO:0000255HAMAP-Rule:MF_03119, ECO:0000269PubMed:19620624}. Cytoplasm {ECO:0000255HAMAP- Rule:MF_03119, ECO:0000269PubMed:19620624}. Cell projection {ECO:0000269PubMed:19620624}. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0042802 identical protein binding
GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity
Biological Process
GO:0000096 sulfur amino acid metabolic process
GO:0006595 polyamine metabolic process
GO:0019284 L-methionine biosynthetic process from S-adenosylmethionine
GO:0019509 L-methionine biosynthetic process from methylthioadenosine
GO:0034641 cellular nitrogen compound metabolic process
GO:0044237 cellular metabolic process
GO:0044249 cellular biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0042995 cell projection
Protein Structure and Domains
PDB ID
InterPro IPR000649 Initiation factor 2B-related
IPR005251 Methylthioribose-1-phosphate isomerase
IPR011559 Initiation factor 2B alpha/beta/delta
PFAM PF01008
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BV20
PhosphoSite PhosphoSite-Q9BV20
TrEMBL
UniProt Splice Variant
Entrez Gene 84245
UniGene Hs.712891
RefSeq NP_001026897
HUGO HGNC:28469
OMIM 615105
CCDS CCDS32923
HPRD 14548
IMGT
EMBL AL834276 AY358176 BC001703 CH471106
GenPept AAH01703 AAQ88543 CAD38951 EAW84370 EAW84371

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca