InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CERS5

Summary

InnateDB Protein

IDBP-32438.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CERS5

Protein Name

ceramide synthase 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000325485

InnateDB Gene

IDBG-32436 (CERS5)

Protein Structure

UniProt Annotation

Function

Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus membrane {ECO:0000255PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0050291	sphingosine N-acyltransferase activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006665	sphingolipid metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046513	ceramide biosynthetic process