InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLXNB1

Summary

InnateDB Protein

IDBP-32485.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLXNB1

Protein Name

plexin B1

Synonyms

PLEXIN-B1; PLXN5; SEP;

Species

Homo sapiens

Ensembl Protein

ENSP00000351338

InnateDB Gene

IDBG-32481 (PLXNB1)

Protein Structure

UniProt Annotation

Function

Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. {ECO:0000269PubMed:12196628, ECO:0000269PubMed:12198496, ECO:0000269PubMed:15210733, ECO:0000269PubMed:19843518, ECO:0000269PubMed:20877282, ECO:0000269PubMed:21912513}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 3: Secreted.

Disease Associations

Tissue Specificity

Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. {ECO:0000269PubMed:8570614}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity
GO:0030215	semaphorin receptor binding
GO:0032794	GTPase activating protein binding

Biological Process

GO:0007162	negative regulation of cell adhesion
GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0008360	regulation of cell shape
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477	cell migration
GO:0032321	positive regulation of Rho GTPase activity
GO:0033689	negative regulation of osteoblast proliferation
GO:0035556	intracellular signal transduction
GO:0043931	ossification involved in bone maturation
GO:0048812	neuron projection morphogenesis
GO:0050772	positive regulation of axonogenesis
GO:0051493	regulation of cytoskeleton organization
GO:0071526	semaphorin-plexin signaling pathway
GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis

Cellular Component

GO:0002116	semaphorin receptor complex
GO:0005576	extracellular region
GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001627 Sema domain
IPR002165 Plexin
IPR002909 IPT domain
IPR008936 Rho GTPase activation protein
IPR013548 Plexin, cytoplasmic RasGAP domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold

PFAM

PF01403
PF01437
PF01833
PF08337

PRINTS

PIRSF

SMART

SM00630
SM00429
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O43157