Version 5.4
Homo sapiens Gene: PLXNB1
Summary
InnateDB Gene IDBG-32481.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLXNB1
Gene Name plexin B1
Synonyms PLEXIN-B1; PLXN5; SEP
Species Homo sapiens
Ensembl Gene ENSG00000164050
Encoded Proteins
IDBP-32485
plexin B1
IDBP-32487
plexin B1
IDBP-375920
plexin B1
IDBP-375926
plexin B1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:48403854-48430051
Strand Reverse strand
Band p21.31
Transcripts
ENST00000358536 ENSP00000351338
ENST00000296440 ENSP00000296440
ENST00000456774 ENSP00000414199
ENST00000449094 ENSP00000395987
ENST00000485535
ENST00000483753
ENST00000497627
ENST00000483676
ENST00000478171
ENST00000470525
ENST00000461261
ENST00000473996
ENST00000465117
ENST00000467913
ENST00000464294
ENST00000484485
ENST00000462738
ENST00000466353
ENST00000473683
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0017154 semaphorin receptor activity
GO:0030215 semaphorin receptor binding
GO:0032794 GTPase activating protein binding
Biological Process
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0007275 multicellular organismal development
GO:0007411 axon guidance
GO:0008360 regulation of cell shape
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477 cell migration
GO:0032321 positive regulation of Rho GTPase activity
GO:0033689 negative regulation of osteoblast proliferation
GO:0035556 intracellular signal transduction
GO:0043931 ossification involved in bone maturation
GO:0048812 neuron projection morphogenesis
GO:0050772 positive regulation of axonogenesis
GO:0051493 regulation of cytoskeleton organization
GO:0071526 semaphorin-plexin signaling pathway
GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
Cellular Component
GO:0002116 semaphorin receptor complex
GO:0005576 extracellular region
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053646
View Gene Order
ENSBTAG00000013407
Not yet available
Pathways
NETPATH
REACTOME
REACT_18407
G alpha (12/13) signalling events pathway
REACT_19266
Sema4D mediated inhibition of cell attachment and migration pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_14797
Signaling by GPCR pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.476209
RefSeq NM_001130082 NM_002673 XM_005265234 XM_006713206
HUGO
OMIM
CCDS CCDS2765
HPRD 03032
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca