Version 5.4
Homo sapiens Protein: LIMA1
Summary
InnateDB Protein IDBP-32506.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIMA1
Protein Name LIM domain and actin binding 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000340184
InnateDB Gene IDBG-32504 (LIMA1)
Protein Structure
UniProt Annotation
Function Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. {ECO:0000269PubMed:12566430}.
Subcellular Localization Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=This cytoskeletal protein co- localizes with actin stress fibers and focal adhesion plaques.
Disease Associations
Tissue Specificity Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003785 actin monomer binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0051015 actin filament binding
Biological Process
GO:0030835 negative regulation of actin filament depolymerization
GO:0031529 ruffle organization
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001781 Zinc finger, LIM-type
PFAM PF00412
PRINTS
PIRSF
SMART SM00132
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UHB6
PhosphoSite PhosphoSite-Q9UHB6
TrEMBL F8VVQ7
UniProt Splice Variant
Entrez Gene 51474
UniGene Hs.525419
RefSeq NP_057441
HUGO HGNC:24636
OMIM 608364
CCDS CCDS8802
HPRD 09755
IMGT
EMBL AB209512 AC008147 AC139016 AF157325 AF198454 AF198455 AF218025 AK000057 AK000335 AK000372 AK023649 AK314447 AL136911 BC001247 BC010664 BC110815 BC136763 CH471111
GenPept AAF23755 AAF23756 AAF67491 AAG17267 AAH01247 AAH10664 AAI10816 AAI36764 BAA90914 BAA91092 BAA91120 BAB14625 BAD92749 BAG37056 CAB66845 EAW58135

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca