Version 5.4
Homo sapiens Gene: LIMA1
Summary
InnateDB Gene IDBG-32504.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIMA1
Gene Name LIM domain and actin binding 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000050405
Encoded Proteins
IDBP-32506
LIM domain and actin binding 1
IDBP-240557
LIM domain and actin binding 1
IDBP-590602
LIM domain and actin binding 1
IDBP-592103
LIM domain and actin binding 1
IDBP-584679
LIM domain and actin binding 1
IDBP-597802
LIM domain and actin binding 1
IDBP-583243
LIM domain and actin binding 1
IDBP-585801
LIM domain and actin binding 1
IDBP-587851
LIM domain and actin binding 1
IDBP-596137
LIM domain and actin binding 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:50175788-50283546
Strand Reverse strand
Band q13.12
Transcripts
ENST00000341247 ENSP00000340184
ENST00000394943 ENSP00000378400
ENST00000552491 ENSP00000448463
ENST00000547825 ENSP00000448706
ENST00000552823 ENSP00000450266
ENST00000552783 ENSP00000448779
ENST00000552909 ENSP00000450087
ENST00000552720 ENSP00000448411
ENST00000549064
ENST00000552338
ENST00000552008
ENST00000552045
ENST00000551486
ENST00000550611
ENST00000551691 ENSP00000447975
ENST00000550592 ENSP00000449890
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003785 actin monomer binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0051015 actin filament binding
Biological Process
GO:0030835 negative regulation of actin filament depolymerization
GO:0031529 ruffle organization
GO:0051017 actin filament bundle assembly
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023022
View Gene Order
ENSBTAG00000012342
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.525419
RefSeq NM_001113546 NM_001113547 NM_001243775 NM_016357
HUGO
OMIM
CCDS CCDS44877 CCDS55826 CCDS58230 CCDS8802
HPRD 09755
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca