InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRHR

Summary

InnateDB Protein

IDBP-32512.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRHR

Protein Name

thyrotropin-releasing hormone receptor

Synonyms

TRH-R;

Species

Homo sapiens

Ensembl Protein

ENSP00000309818

InnateDB Gene

IDBG-32510 (TRHR)

Protein Structure

UniProt Annotation

Function

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004997	thyrotropin-releasing hormone receptor activity

Biological Process

GO:0007186

G-protein coupled receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002120 Thyrotropin-releasing hormone receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00751
PR01654
PR01846

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P34981