InnateDB Protein
|
IDBP-32584.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
HERPUD1
|
Protein Name
|
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
|
Synonyms
|
HERP; Mif1; SUP;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000340931
|
InnateDB Gene
|
IDBG-32578 (HERPUD1)
|
Protein Structure
|
|
Function |
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. {ECO:0000269PubMed:16289116}.
|
Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:10922362}; Multi-pass membrane protein {ECO:0000269PubMed:10922362}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
37
[view]
|
Protein-Protein |
37
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006986
|
response to unfolded protein
|
GO:0006987
|
activation of signaling protein activity involved in unfolded protein response
|
GO:0030968
|
endoplasmic reticulum unfolded protein response
|
GO:0044267
|
cellular protein metabolic process
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR000626
Ubiquitin-like
IPR029071
Ubiquitin-related domain
|
PFAM |
PF00240
PF14560
|
PRINTS |
|
PIRSF |
|
SMART |
SM00213
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q15011
|
PhosphoSite |
PhosphoSite-Q15011
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
9709
|
UniGene |
Hs.644753
|
RefSeq |
|
HUGO |
HGNC:13744
|
OMIM |
608070
|
CCDS |
|
HPRD |
07456
|
IMGT |
|
EMBL |
AB034989
AB034990
AC012181
AF055001
AF055003
BC000086
BC008320
BC009739
BC032673
CR457116
D14695
|
GenPept |
AAC09355
AAC09357
AAH00086
AAH08320
AAH09739
AAH32673
BAA03521
BAB07891
BAB19010
CAG33397
|
|
|