Version 5.4
Homo sapiens Gene: HERPUD1
Summary
InnateDB Gene IDBG-32578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HERPUD1
Gene Name homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
Synonyms HERP; Mif1; SUP
Species Homo sapiens
Ensembl Gene ENSG00000051108
Encoded Proteins
IDBP-32580
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IDBP-32582
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IDBP-32584
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IDBP-377463
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IDBP-750710
IDBP-754287
IDBP-745257
IDBP-749908
IDBP-748166
IDBP-745038
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involved in polypeptide folding, known as the unfolded protein response (UPR), and the destruction of misfolded proteins by the ER-associated protein degradation (ERAD) system. This gene may play a role in both UPR and ERAD. Its expression is induced by UPR and it has an ER stress response element in its promoter region while the encoded protein has an N-terminal ubiquitin-like domain which may interact with the ERAD system. This protein has been shown to interact with presenilin proteins and to increase the level of amyloid-beta protein following its overexpression. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. The full-length nature of all transcript variants has not been determined. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:56932048-56944863
Strand Forward strand
Band q13
Transcripts
ENST00000300302 ENSP00000300302
ENST00000379792 ENSP00000369118
ENST00000344114 ENSP00000340931
ENST00000439977 ENSP00000409555
ENST00000566550
ENST00000563343 ENSP00000455094
ENST00000565966 ENSP00000456384
ENST00000568651 ENSP00000457955
ENST00000570273
ENST00000567944
ENST00000568676
ENST00000564678
ENST00000568358 ENSP00000457095
ENST00000563911 ENSP00000455841
ENST00000562914
ENST00000568814
ENST00000563781
ENST00000569569
ENST00000569429 ENSP00000457321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006874 cellular calcium ion homeostasis
GO:0006986 response to unfolded protein
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031396 regulation of protein ubiquitination
GO:0032092 positive regulation of protein binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031770
View Gene Order
ENSBTAG00000016896
Not yet available
Pathways
NETPATH
REACTOME
REACT_18355
ATF4 activates genes pathway
REACT_18277
PERK regulates gene expression pathway
REACT_18356
Unfolded Protein Response (UPR) pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q15011
TrEMBL B4DXX2 B4E3N8 H3BP08 H3BRS4 H3BTT7 Q9HBR2
UniProt Splice Variant
Entrez Gene 9709
UniGene Hs.146393 Hs.644753
RefSeq NM_001010989 NM_001272103 NM_014685 XM_006721352
HUGO HGNC:13744
OMIM 608070
CCDS CCDS10771 CCDS45492
HPRD
IMGT
EMBL AB034989 AB034990 AC012181 AF055001 AF055003 AF217990 AK302167 AK304800 BC000086 BC008320 BC009739 BC032673 CR457116 D14695
GenPept AAC09355 AAC09357 AAG17233 AAH00086 AAH08320 AAH09739 AAH32673 BAA03521 BAB07891 BAB19010 BAG63534 BAG65550 CAG33397
RNA Seq Atlas 9709

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca