InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIPG

Summary

InnateDB Protein

IDBP-3263.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIPG

Protein Name

lipase, endothelial

Synonyms

EDL; EL; PRO719;

Species

Homo sapiens

Ensembl Protein

ENSP00000261292

InnateDB Gene

IDBG-3261 (LIPG)

Protein Structure

UniProt Annotation

Function

Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004465	lipoprotein lipase activity
GO:0004620	phospholipase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008970	phosphatidylcholine 1-acylhydrolase activity
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0007584	response to nutrient
GO:0008283	cell proliferation
GO:0009395	phospholipid catabolic process
GO:0010983	positive regulation of high-density lipoprotein particle clearance
GO:0032376	positive regulation of cholesterol transport
GO:0034375	high-density lipoprotein particle remodeling
GO:0042632	cholesterol homeostasis
GO:0043691	reverse cholesterol transport
GO:0050746	regulation of lipoprotein metabolic process
GO:0055091	phospholipid homeostasis

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000734 Lipase
IPR001024 PLAT/LH2 domain
IPR002330 Lipoprotein lipase
IPR002333 Hepatic lipase
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein lipase, LIPH
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF01477
PF00151

PRINTS

PR00821
PR00822
PR00824

PIRSF

PIRSF000865

SMART

SM00308

TIGRFAMs

Post-translational Modifications

Modification

Cross-References