Version 5.4
Homo sapiens Gene: LIPG
Summary
InnateDB Gene IDBG-3261.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LIPG
Gene Name lipase, endothelial
Synonyms EDL; EL; PRO719
Species Homo sapiens
Ensembl Gene ENSG00000101670
Encoded Proteins
IDBP-3263
lipase, endothelial
IDBP-369217
lipase, endothelial
IDBP-727935
IDBP-725621
IDBP-726807
IDBP-727437
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:49560699-49599182
Strand Forward strand
Band q21.1
Transcripts
ENST00000261292 ENSP00000261292
ENST00000427224 ENSP00000387978
ENST00000577628 ENSP00000463835
ENST00000580036 ENSP00000462420
ENST00000579750 ENSP00000462480
ENST00000583083 ENSP00000463077
ENST00000623277
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004465 lipoprotein lipase activity
GO:0004620 phospholipase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0008970 phosphatidylcholine 1-acylhydrolase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007584 response to nutrient
GO:0008283 cell proliferation
GO:0009395 phospholipid catabolic process
GO:0010983 positive regulation of high-density lipoprotein particle clearance
GO:0032376 positive regulation of cholesterol transport
GO:0034375 high-density lipoprotein particle remodeling
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0050746 regulation of lipoprotein metabolic process
GO:0055091 phospholipid homeostasis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000053846
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B4DTR8 J3KTN7
UniProt Splice Variant
Entrez Gene 9388
UniGene Hs.465102 Hs.618013
RefSeq NM_006033
HUGO HGNC:6623
OMIM 603684
CCDS CCDS11938
HPRD 04730
IMGT
EMBL AC091170 AK300333
GenPept BAG62080
RNA Seq Atlas 9388

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca