InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL27RA

Summary

InnateDB Protein

IDBP-32725.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL27RA

Protein Name

interleukin 27 receptor, alpha

Synonyms

CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1;

Species

Homo sapiens

Ensembl Protein

ENSP00000263379

InnateDB Gene

IDBG-32723 (IL27RA)

Protein Structure

UniProt Annotation

Function

Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms. {ECO:0000269PubMed:14764690}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B- cells and monocytes. {ECO:0000269PubMed:11057672, ECO:0000269PubMed:9600072}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005515	protein binding
GO:0045509	interleukin-27 receptor activity

Biological Process

GO:0002827	positive regulation of T-helper 1 type immune response
GO:0002829	negative regulation of type 2 immune response
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0032729	positive regulation of interferon-gamma production
GO:0048302	regulation of isotype switching to IgG isotypes
GO:0050830	defense response to Gram-positive bacterium
GO:0070106	interleukin-27-mediated signaling pathway