InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYSLTR2

Summary

InnateDB Protein

IDBP-32794.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYSLTR2

Protein Name

cysteinyl leukotriene receptor 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000282018

InnateDB Gene

IDBG-32792 (CYSLTR2)

Protein Structure

UniProt Annotation

Function

Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation by BAY u9773, a partial agonist, induces specific contractions of pulmonary veins and might also have an indirect role in the relaxation of the pulmonary vascular endothelium. The rank order of affinities for the leukotrienes is LTC4 = LTD4 >> LTE4.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in the heart, placenta, spleen, peripheral blood leukocytes and adrenal gland. In lung, expressed in the interstitial macrophages, and slightly in smooth muscle cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001631	cysteinyl leukotriene receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004974	leukotriene receptor activity
GO:0005515	protein binding

Biological Process

GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0010942	positive regulation of cell death
GO:0045766	positive regulation of angiogenesis
GO:0050909	sensory perception of taste
GO:0070374	positive regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005575	cellular_component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR003912 Protease-activated receptor
IPR004071 Cysteinyl leukotriene receptor
IPR007960 Mammalian taste receptor
IPR013311 Cysteinyl leukotriene receptor 2
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001
PF05296

PRINTS

PR00237
PR01428
PR01533
PR01903

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NS75